Sentence examples for bind to its consensus from inspiring English sources

FOXO3a transcription factor is able to bind to its consensus DNA-binding motif - TTGTTTAC - in the promoter regions of several of these atrogenes, including Atrogin-1, LC3, Bnip3 and Gabarapl1 [ 13- 15].

In the past it has been shown that p53 can bind to its consensus sequences and recruit the yeast transcription machinery to start expression of downstream genes [9] [11], a process that can be inhibited by co-expression with Mdm2 [4].

Altogether, p53 can directly bind to its consensus element (p53RE2) in miR-509-5p miR-509-5p miR-509-5p in the induction of miR-509-5promoter that resultses Mdm2 actinitheto inductionthe p53 level.

A three-dimensional model of the PRH homeodomain bound to its consensus DNA sequence was built using sequence alignment and molecular modelling methods [ 29].

If not already constitutively expressed in the cell nucleus, the NR dimer travels from the cytoplasm into the nucleus, binds to its specific consensus sequence in target gene promoters and modulates gene expression.

The yeast HXT (glucose transporter gene) repressor Rgt1 lacks a dimerization domain and thus appears to bind as a monomer to its consensus binding site sequence (5′-CGGANNA-3′).

The activated p53 binds to its DNA-binding consensus sequence that is present in its target genes [15].

Binding of activated calcium-calmodulin to its consensus sequence on eNOS initiates catalytic activity.

It has been well established that βTrCP1 binds to its substrates through the consensus degron domain "DSGxxS," where both serines (S) are phosphorylated by kinases [26].

NFATc1 binds to its response elements containing a consensus sequence of GGAAA, and its target genes in osteoclasts include cathepsin K, CLC-7 chloride channel, vacuolar proton pump subunit Atp6v0d2, etc (Kuroda and Matsuo, 2012).

In conclusion, we have made the novel observation that inhibition of TNFα- and IL-1β-induced MCP-1 expression from human ASM cells by the glucocorticoid ciclesonide is mediated via a transcriptional mechanism that it not dependent on IκB degradation but, rather, on the ability of TNFα- and IL-1β-induced NF-κB p65 to bind its consensus binding site.