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But a working definition of cell status may be almost at hand, in Dr. Lander's view, in terms of a cell's chromatin state and the transcription factors that can bind to its available genes.
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The effects of TH are determined by the intracellular concentration of triiodothyronine (T3) available to bind to its nuclear receptor [ 1, 3– 5].
We also computed the molar ratio of IGF-I to IGFBP-3 (IGF-I/IGFBP-3 ratio) as a marker of the estimated level of IGF-I biologically available to bind to its receptor.
If the expression level of an mRNA is increased, more copies of its targeting miRNAs will bind to it and become less available for binding other targets.
Free IL-1 binds to its specific sIL-1R, resulting in less IL-1 being available to bind to the membrane-specific receptor.
"I'm a tracker and if you have that skill, you are duty bound to make it available.
Without a specific signal to express the gene, further TF molecules may continue to bind to the available and recognizable binding motifs.
First, most of the gp120-specific mAbs showed neutralizing activity (37 out of 58), indicating that they bind to sites available on the functional Env trimer.
Chemisorption energies are shown in Table 1, from which we see that NH3 molecules will always bind to available dangling bonds.
In the presence of a surface, we suggest the [Mn III 6 Cr III ] 3+ trication could adsorb on the surface without the need of interaction with anions and bind to available adsorption sites on the substrate.
However, dynein prefers to rotate to the right, suggesting that with every step along a microtubule, it binds to the closest available binding site in the forward direction.
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