Sentence examples for bind to inactive from inspiring English sources

Type II inhibitors bind to inactive conformation.

In this issue of Chemistry & Biology, Okram et al. [1] tackle this issue and show that inhibitors can be designed specifically to bind to inactive Abl.

APPL1 has previously been shown to bind to inactive Akt (Mitsuuchi et al., 1999).

Weber et al. used RNAP II occupancy as proxy for expression, which may be problematic because RNAP II can also bind to inactive genes.

Imatinib binding can be directly inhibited by mutations involving the ATP-binding pocket, 99, 100 and mutations involving the activation loop could strongly increase the proportion of KIT in active conformation, decreasing the possibility of KIT to bind to inactive forms.

To assess the validity of using monomeric CDK2 as a model for the active kinase in structure-based drug design, we have solved the structure of the inhibitor indirubin-5-sulphonate (E226) complexed with phospho-CDK2-cyclin A and compared it with the structure of E226 bound to inactive, monomeric CDK2.

Both isoforms, however, bound to inactive Rac1 through the same non-exon 10 site.

Ttk69 is mainly bound to inactive enhancers associated with genes exclusively expressed in FCs.

By soaking erlotinib into crystals formed by a V924R-mutated EGFR-TKD variant, we were able to determine the structure of erlotinib bound to inactive EGFR-TKD at a resolution of 2.75 Å (Table 1).

Laufer's group has developed a conformation-specific fluorescent polarization binding assay that was implemented to identify p38 inhibitors that preferably bind to the inactive conformation of the kinase.

Experimental results indicate that inactive ATM exists as a dimer [16], and thus we can assume two phosphorylated ATMs bind to an inactive ATM dimer.