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These splicing factors bind to important sequences in the pre-mRNA, which include donor and acceptor splice sites, branch points (BP), pyrimidine tracts and exon splicing enhancers (ESEs) [35].
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Small molecules can bind to these sequences and stabilize the resulting quadruplex structures.
Transcription factors, important mediators involved in signal transduction, bind to specific DNA sequences within gene promoters, and thus regulate transcriptional activity.
However, the FoxO1 S218DNA-bindingng domain was unable to bind to this sequence (Fig. 3b).
An important determinant of gene promoter selectivity of activated ERs in vertebrates is their ability to bind to sequences of DNA called estrogen response elements (EREs) within the promoter of target genes (Hall et al., 2001).
5) Radioactive DNA probes are applied to the membrane and bind to matching DNA sequences.
SH3 domains bind to proline rich sequences.
KLF17 has been known to bind to CACCC box sequences.
For instance, methyl molecules can bind to the sequence and block access to genes.
HnRNP A3 has been reported to bind to the telomere sequence, likely playing an important role in its maintenance [26], and to the 3'-UTR region of the cyclooxygenase-2 gene, playing a role in lipopolysaccharide signal transduction [10].
CCCTC-binding factor (CTCF), which is bound to transposable element sequences within the rDNA, plays an important role in regulation of rDNA and nucleolar stability in Drosophila.
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