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Notably, Anti-MUC1* produced heavier staining than VU4H5 despite the fact that the tandem repeat antibody can bind to hundreds of epitopes per receptor compared to the single epitope to which Anti-MUC1* binds.
10.7554/eLife.06942.013 Figure 2. NKX2-5 mutants bind to hundreds of targets in HL-1 cells.
A particular miRNA may bind to hundreds of different genes, sometimes even onto multiple sites for a given target mRNA.
Each miR is able to bind to hundreds of target mRNAs, thus they represent a potent group of regulators of gene expression.
For example, RNA-immunoprecipitation profiling studies have shown that individual Puf proteins can bind to hundreds of unique transcripts in vivo [ 15- 18].
In mammals, a single miRNA can bind to hundreds of targets by complementation of the miRNA seed region to the 3′ UTR binding site of the target, thus reducing gene expression by translational suppression and mRNA destabilization.
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Frontrunners in the targeted delivery arena are DNA Nanoparticles (DNs), such as DNA origami, which are composed of a long single-strand of DNA or scaffold that folds into any one of a variety of shapes and sizes when it binds to hundreds of short DNA strands, called staples.
They found that CHD8 binds to thousands of targets in each tissue.
The mammalian Myc oncoprotein is a transcription factor that binds to thousands of promoters.
Wnt proteins bind to seven-transmembrane Frizzled receptors to mediate the important developmental, morphogenetic, and stem cell related tissue-regenerative effects of Wnt signaling.
open cluster Loosely bound collection of tens to hundreds of stars, a few parsecs across, generally found in the plane of the Milky Way.
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