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Bacterial expression of so-called microbial surface components recognizing adhesive matrix molecules has the capacity to bind to human matrix proteins such as fibrinogen or fibronectin [ 23].
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Rheumatoid factors (RFs) are endogenous human antibodies that bind to human gamma globulins.
Using cultured human thymic epithelial (TE) cells, we have found that human thymocytes bind to human TE cells in vitro.
Thus, JL2 could bind to human SCARB2 on the plasma membrane.
An additional negative control peptide containing an epitope from the influenza matrix protein (M158 66) which binds to human MHC class I molecules was also synthesized.
Codrituzumab is a recombinant, fully humanized mAb that binds to human GPC3.
Presumably IgG antibodies form immune complexes with CII in the cartilage matrix and initiate the complement cascade to provoke an inflammatory reaction within the joint that causes degradation of the cartilage matrix, noting that purified anti-CII from RA serum activates complement C5 to C5a when bound to human cartilage in vitro [ 2].
JL2 binds to human SCARB2 but not mouse SCARB2.
Colistin is approximately 50% bound to human plasma.
The radiolabeled product bound to human Raji cells with a nanomolar K d value.
PMB was ∼51% bound to human plasma proteins.
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