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S. pneumoniae expresses a 75-kDa surface protein, Choline- binding protein A (CbpA) which has been shown to bind to host cells via secreted complement component C3 [ 20- 22].
The present study draws a parallel with the research work of Bessone (2010) and Kishida et al. (2012) who reported that liver injury resulted from NSAIDs may be proposed to their acidic moiety or reactive metabolites that bind to host proteins causing cellular injury.
Overall, we show here that δ-toxin is able to bind to host AMPs.
Indeed, several PAN domain-containing microneme proteins have been identified [35], [94]–[97], and TgMIC4 has been shown to bind to host cells [35].
The OMVs from E. coli and P. aeruginosa bind to host cells via lipid rafts, after which bacterial effector molecules are translocated into the cytosolic compartment [20], [23].
Human LL-37 has the ability to bind to host DNA and serve as an activating ligand for TLR9 in plasmacytoid dendritic cells [16].
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Iron availability within cells is substantially different than in the extracellular milieu, where iron is scarce and often tightly bound to host iron-binding proteins (IBPs).
Previous structures of Crm1 bound to host cargo proteins have shown monomeric binding, so we sought to understand how Rev-RRE organizes a Crm1 dimer.
In the presence of 50 μmol/L compound, the virus bound to host cell in two conditions decreased to less than 20% of that seen in the absence of compound.
The virulence of Bacillus anthracis is critically dependent on the cytotoxic components of the anthrax toxin, lethal factor (LF) and edema factor (EF). LF and EF gain entry into host cells through interactions with the protective antigen (PA), which binds to host cellular receptors such as CMG2.
County Supervisor Zev Yaroslavsky said he would have liked to immediately postpone all future raves but has been told by the Coliseum's lawyers that the venue is contractually bound to host them.
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