Sentence examples for bind to distinct epitopes from inspiring English sources
MP0274 is another multimer composed of two DARPins that bind to distinct epitopes on the human epidermal growth factor receptor 2 (HER2) and inhibits downstream HER2- and HER3-mediated signaling.
ELISA can effectively minimize false positive results because the detection signal is generated only when both antibodies independently bind to distinct epitopes on the same target protein.
Conventional ELISAs detect a target analyte via a sandwich complex composed of two affinity agents that bind to distinct epitopes on the analyte.
Although both pertuzumab and trastuzumab target HER2, they bind to distinct epitopes, and consequently, ligand-activated downstream signalling induced by heterodimerisation is blocked by pertuzumab but not by trastuzumab.
Binding to distinct epitopes on the same anchoring molecule may lead to different outcomes.
Ligands binding to distinct epitopes on the same target molecule may influence each other, for example, inhibiting binding to adjacent epitopes.
Lectin has the capability to bind to distinct oligosaccharide epitopes.
An approach for enhancing antibody affinity is to engineer Chelating Recombinant Antibodies (CRAbs) which consist of two tandemly linked single-chain Fvs (scFvs) that bind to distinct non-overlapping epitopes on the antigen molecule leading to a synergistic decrease in KD.
Monoclonal antibodies JIM5 and JIM7 bind to distinct partially methylesterified epitopes of pectic homogalacturonan (HG), with JIM5 for low-esterified and JIM7 for high-esterified pectins.
We show that tumour cells that acquire resistance to anti-EGFR mAb ICR62 also acquire resistance to treatment with mAbs cetuximab and ICR61, both of which bind to other distinct epitopes on the extracellular domain of the EGFR, but interestingly, these cells remain sensitive to pan-HER family inhibitors.
