Sentence examples for bind to disordered partners from inspiring English sources

However, it has proven very difficult to globally test whether structured hubs bind to disordered partners.

Even though 14-3-3 14-3-3 14-3-3to disordered regions in its partners (data herein and [ 63]), this idea of blikelyg the active structure could still bindsue.

Motivation: Molecular recognition features (MoRFs) are short binding regions located within longer intrinsically disordered regions that bind to protein partners via disorder-to-order transitions.

Our recent study of the complexes that form when various disordered segments bind to ordered partners indicates that the disorder-associated binding regions have distinct sequence features, even when the bound structure is irregular or sheet instead of helix, and so it should be feasible to develop a specific predictor for each of the different types of MoRFs [ 137].

Here we present a detailed examination of two divergent examples: 1) p53, which uses different disordered regions to bind to different partners and which also has several individual disordered regions that each bind to multiple partners, and 2) 14-3-3, which is a structured protein that associates with many different intrinsically disordered partners.

Chameleon behavior could be an important feature that enables one disordered region to bind to multiple partners.

In that study, we proposed that "one-to-many" signaling be used to describe the capacity of one disordered region to bind to many partners.

These results show very clearly how one segment of disordered protein can bind to multiple partners via the ability to adopt distinct conformations.

Recently we studied the detailed structures for a one-to-many example (namely, p53 using its disordered regions to bind to many partners), and we also studied the structures of a many-to-one example (namely, 14-3-3 usinglets single binding site to associate with many different disordered partners having different amino acid sequences).

These proteins can bind the same partner in different conformations or bind to completely different partners through the disordered binding regions [ 122].

On the basis of these observations, it has been concluded that "modulation of allostery using intrinsically disordered protein regions that can bind to diverse partners may be a mechanism by which a promiscuous molecular hub IDP can manage its functional complexity".