Sentence examples for bind to different targets from inspiring English sources
Based on the mechanisms of action, dual-targeting BsAb can be constructed to bind to different targets of the signaling pathways within the same diseased cells.
This (indirect) diversity measure has its disadvantages as similar ligands can bind to different targets or alternatively, structurally diverse ligands may bind to the same target.
mAbs that bind to different targets may not be directly comparable based on pI alone; individual mAbs against different targets have their own physicochemical characteristics that may uniquely contribute to PK properties.
Since a compound may be able to bind to different targets in different conformations, the algorithm aligns pairs of pharmacophore models sharing the same features which are not necessarily at the exactly same spatial distance.
BsAb can also be designed to bind to different targets expressed on different cell populations within the diseased tissues to achieve synergistic therapeutic effects and/or to enhance specific tissue distribution [55].
Toxins that share similar structures, despite no notable sequence similarities, bind to different targets (e.g. CcdB binds to DNA gyrase but Kid, which has similar structure as CcdB, cleaves free mRNAs) (Hargreaves et al., 2002).
Moreover, since different aptamer can specifically bind to different target molecules, the designed strategy has an expansive application for the construction of versatile PEC platforms.
Homology between the N-terminal domains of SRRPs from pig and rodent strains was lower (~50%% aa identity), suggesting that they may share a common structure but bind to different target ligands in their respective hosts.
The number of different Hox proteins is relatively small, but they are able to target a wide spectrum of other genes, with their ability to bind to different target genes being modulated via interactions with other proteins known as co-factors.
