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These ligands may occupy very similar and overlapping binding regions, while the rest of the ligands bind to different regions within the QZ59-RRR-associated binding site.
The mechanisms underlying these effects suggest the participation of a great variety of proteins that bind to different regions of Cx43.
However, despite the common specificity for methylated histone H3, the three HP1 isoforms bind to different regions of the genome.
Most eukaryotes have at least three HP1 isoforms [1], which are conserved in overall structure but bind to different regions within the genome [2].
We demonstrate that these antibodies bind to different regions of LRP6 protein, and inhibition of signaling results from blocking Wnt binding.
As ryanoids and IpTxA were shown to bind to different regions in the RyR molecule [55], [56], our finding that protamine affects the action of both agents would suggest multiple sites of action or allosteric effects.
Similar(47)
The interpretation of this result is that CENP-A binds to different regions in the two homologs, as in horses HSF-C and HSF-G.
These compounds bound to the pocket with an affinity similar to locostatin; however, their side chains allowed for binding to different regions within the RKIP binding pocket.
i.e., by producing multiple Ssps that bind to different chromosomal regions depending on their local AT% ratio, the entire chromosome can be maximally protected from damage induced by stresses such as heat or preservatives.
Here we present a detailed examination of two divergent examples: 1) p53, which uses different disordered regions to bind to different partners and which also has several individual disordered regions that each bind to multiple partners, and 2) 14-3-3, which is a structured protein that associates with many different intrinsically disordered partners.
Since the overall trends for residues that shifted in Ca2+-S100B Ca2+-S100Bsimilar for IC3-C58 and its subpeptides IC3-M28 and IC3-C30 (Supporting Information Figure S4), attempts were also made to fit the data for 2:1 stoichiometry (i.e., two IC3-M28 peptides to each Ca2+-S100B protomer) assuming that each peptide might bind to two different regions akin to the intact IC3-C58 peptide.
More suggestions(17)
bind to other regions
bind to different aptatopes
bind to genomic regions
bind to different promoters
bind to different HLAs
bind to similar regions
bind to untranslated regions
bind to different types
bind to specific regions
bind to certain regions
bind to different species
bind to different subsets
bind to nucleosomal regions
bind to regulatory regions
bind to different sizes
bind to different sites
bind to different sections
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