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Just because the two domains bind to different ligands simultaneously, galectin-4 can be a crosslinker and crucial regulator in a large number of biological processes.
RACK1 forms a propeller-like structure that contains seven "blades" (domains 1 to 7), which consist of WD40 repeats that can bind to different ligands [42].
Nuclear medicine imaging involves imaging radiotracers, which can bind to different ligands.
The different isoforms may bind to different ligands that mediate the differential neuroprotective effects.
Although they bind to different ligands, they identify each other during sequence searches and display 23 29% sequence identity.
Nrps are known as multi-functional co-receptors that bind to different ligands in different cell types (Gu et al., 2003; Gitler et al., 2004; Pellet-Many et al., 2008).
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Molecular modeling was assessed using MOE software (Molecular Operating Environment Chemical Computing Groupp, Inc .. Two PDB Protein Data Bankk; http://www.wwpdb.org/) crystal structures, 4EMA and 2HFP, constituting the human PPARγ ligand-binding domain bound to different ligands, were compared.
Each HLA allotype binds to different ligands characterized by specific binding motifs [ 91].
To optimize a lead compound, research labs need to routinely and rapidly solve dozens of structures of a protein bound to different ligands, to find which offers the most favourable interactions.
Writing in Nature, Laverty et al.1 and Masiulis et al.2 report the 3D high-resolution structures of an isoform of the GABAA receptor bound to different ligands in physiologically relevant conformations.
Using "monobodies," small antibody mimics based on the fibronectin type III domain, as the target-binding proteins, we demonstrated the effectiveness of our method by separating the active form of the estrogen receptor α ligand-binding domain (ERα-LBD) from a mixture of active and misfolded species and by discriminating two different conformations of ERα-LBD bound to different ligands.
More suggestions(17)
bind to diverse ligands
bound to different ligands
bind to different aptatopes
bind to multiple ligands
bind to different promoters
bind to different HLAs
bind to different types
bind to different regions
bind to such ligands
bind to different species
bind to different subsets
bind to different epitopes
bind to different materials
bind to different sizes
bind to specific ligands
bind to different sites
bind to different sections
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