Sentence examples for bind to different epitopes from inspiring English sources

Trastuzumab and pertuzumab bind to different epitopes in the extracellular domain of HER2, with trastuzumab binding domain IV of the extracellular domain [ 54] and pertuzumab binding near the junction of domains I, II, and III of the HER2 extracellular domain [ 55].

Further, BsAb can be created from two antibodies that bind to different epitopes on the same target (i.e., bi-paratopic binding) to enhance binding avidity [56] and to increase antibody load on tumor cells for enhanced effector functions, such as ADCC and/or CDC [53].

Polyclonal antibodies are a heterogeneous mixture of antibodies that bind to different epitopes of the same protein.

The method is based on the two murine monoclonal antibodies that bind to different epitopes of insulin, but do not bind to proinsulin.

In a competition assay, 10C3 and 4E10 did not compete with 2A12, while 4E10 partially competed with 10C3, suggesting that these three clones bind to different epitopes on MIF (Fig. 1B).

In this method monoclonal antibody specific to endothelin and acetylcholinesterase: Fab' Conjugate (AChE:Fab') bind to different epitopes on the Endothelin-1 molecule and forming sandwich.

In the present study, we investigated the effects of a panel of four anti-EGF receptor mAbs, each of which binds to different epitopes of the EGF receptor in DiFi cells, on the induction of apoptosis.

Indeed, when treated with cetuximab, which binds to different epitopes on the EGFR extracellular domain, DiFi62 cells maintained EGFR, HER2 and HER-3 activities, as well as Akt- and MAPK-mediated signalling.

Pertuzumab (Omnitarg) is a humanized IgG1 anti-HER2 antibody that binds to different epitope (s) than that of trastuzumab, and prevents HER2 from both homodimerizing with HER2 and heterodimerizing with HER1 and HER3.

CS-56 and 2H6 bind to different distinct epitopes of CS-A, which are present to various degrees depending on the origin of CS-A [27].

Using recombinant Fab (rFab) fragments derived from GAD65-specific monoclonal antibodies that bind to different conformational epitopes and parts of the protein [34], we performed competitive GAD65 binding assays.