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HS chains bind to different FGFs with reasonable specificity according to its sulfation pattern.
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Date hubs bind to different proteins at different times.
Carrageenan and glycan bind to different sites on AFAL.
These heterodimers bind to different components of the ECM.
In these studies, hSef blocked cell proliferation in response to different FGFs.
Alternative splicing of the IgIII (D3) domain generates the IIIb and IIIc isoforms in FGFRs1 3 [ 142], and each of these isoforms display different affinity to bind to their FGF family members.
Each of these variants can bind to a different antigen.
Instead, the crRNAs bind to a different protein called Cas.
For instance, Lrig1 can also inhibit Met and Ret signaling pathways, while Lrig3 has been shown to bind to the FGF receptor [52] [54].
Crystal structures have revealed that HSPGs bind to the FGF ligand and receptor as a heterotrimeric complex (i.e., FGF-HSPG-FGFR) (Pellegrini et al. 2000).
Intestinal FXR activation due to transintestinal bile acid flux after a meal also induces the expression of fibroblast growth factor (FGF -19, which is released by small intestine epithelial cells and circulates to bind to hepatocyte FGF -19eptor 4 (FGFR4) receptors that signal a reduction in bile acid synthesis via c-Jun NH2-terminal kinase (JNK) pathwhichctisation (2).
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