Sentence examples for bind to complementary target from inspiring English sources

They bind to complementary target sites in mRNA that are often located in 3′ untranslated region (UTR) but can also be found in 5′UTR or even coding region (Forman and Coller, 2010; Li et al., 2011).

siRNA's bind to complementary target mRNA and, upon interaction with the cellular RNA interference mechanisms, will specifically target these sequences for degradation, resulting in inhibition of protein expression [11], [12].

They are approximately 18~25 nucleotides in length and can bind to complementary target sites in mRNA molecules, causing translation repression or the cleavage of the targets [ 10]. miRNAs have been reported to play important roles in a variety of pathophysiological processes [ 11– 13].

Mature miRNAs are processed from primary transcript (pri-miRNA) [ 36] and incorporated into an RNA-induced silencing complex (RISC) that can bind directly to complementary target mRNA transcripts, which are then cleaved or the RISC can reversibly inhibit the translation process [ 37].

Small DNA-like molecules, called peptide nucleic acids (PNAs), can shut down specific genes in cultured cells because their nucleic acid sequence binds tightly to complementary target DNA or RNA sequences, preventing the cell from translating a gene's code into a working protein.

Similarly, microRNAs, post-transcriptional regulators that bind to complementary sequences on target mRNAs, influence mRNA through translational repression or target degradation, which then affects clinical outcome (Tseng et al., 2011).

They are generated from single-strand RNA precursors that are folded into stem-loop structures, and their abilities to bind to complementary sequences of target mRNAs results in cleavage or degradation of the target mRNAs or suppression of their translation [ 1- 3].

MicroRNAs (miRNAs) are post-transcriptional regulators that bind to complementary sequences on target messenger RNA transcripts (mRNAs), usually resulting in translational repression or target degradation and gene silencing [ 8- 10].

In animals, miRNAs bind to complementary sites in target mRNAs, generally at 3' untranslated regions (UTRs), to create imperfectly paired miRNA/mRNA heteroduplexes that inhibit translation or increase degradation of target mRNAs.

MicroRNAs (miRNAs) comprise a specific class of noncoding RNAs that bind to complementary sequences on target mRNAs to repress translation and silence gene expression (Robison and Nestler 2011).

MicroRNAs (miRNAs) are non-coding oligonucleotides, which bind to complementary sites on target genes, leading to translational inhibition or mRNA degradation (Pillai, 2005).