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Bad and Noxa, on the other hand, bind to complementary subsets of anti-apoptotic factors, with Bad interacting strongly with Bcl-2, Bcl-xl and Bcl-w and Noxa binding to Mcl-1 and A1.
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When one or more input strands bind to complementary sequences on the loop, the loop breaks, activating the DNAzyme and switching the gate on.
Usually 25 bases in length, they bind to complementary sequences of RNA by standard nucleic acid base-pairing.
The nucleobases covalently attached to the PNA backbone enable the PNA oligomers to bind to complementary DNA or RNA sequences via Watson-Crick base-pairing.
miRNAs bind to complementary sites within the 3'UTRs of cognate mRNAs, leading to translational repression or cleavage[4] of the targeted messages.
MiRNAs are a species of small regulatory RNA that bind to complementary sequences in mRNA and decrease gene expression by increasing degradation and blocking translation (reviewed in [26]).
MicroRNAs are post-transcriptional regulators that bind to complementary sequences in the 3'UTR of target mRNAs, usually resulting in mRNA degradation and gene silencing [25].
miRNAs are post-transcriptional regulators that bind to complementary sequences in the 3′ UTRs of mRNAs.
They typically bind to complementary loci in the 3′ untranslated region (UTR) of mRNA and prevent translation to mature protein.
For amplification of a band in RAPD analysis same primer has to bind to complementary sites on both strands.
These fragments can bind to complementary transcripts and downregulate their expression via an RNA interference-like mechanism, as explained above.
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