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When one or more input strands bind to complementary sequences on the loop, the loop breaks, activating the DNAzyme and switching the gate on.
However, they can themselves (epi-miRNAs) repress key enzymes that drive epigenetic remodeling and also bind to complementary sequences in gene promoters, recruiting specific protein complexes that modulate chromatin structure and gene expression.
Usually 25 bases in length, they bind to complementary sequences of RNA by standard nucleic acid base-pairing.
MicroRNAs are post-transcriptional regulators that bind to complementary sequences in the 3'UTR of target mRNAs, usually resulting in mRNA degradation and gene silencing [25].
MiRNAs are a species of small regulatory RNA that bind to complementary sequences in mRNA and decrease gene expression by increasing degradation and blocking translation (reviewed in [26]).
These non-coding ∼21 nt long molecules bind to complementary sequences on protein-coding messenger RNAs and as a consequence direct their degradation and/or repress their translation [12], [13].
Similar(37)
Presumably, these antisense DNAs bound to complementary sequences within the targeted spo0A mRNA and inhibited the translation of spo0A, thereby resulting in depression of spore formation in B. subtilis penetrons.
In E. coli, RyhB binds to complementary sequences of target mRNAs, causing their degradation in an RNaseE- and Hfq-dependent manner [23], [24], [25].
They are normally 22 nucleotide RNA that binds to complementary sequences in the 3′UTR to repress gene activities [ 49].
The miRNA binds to complementary sequences within the 3′ mRNA tails, although usually only with partial base pair complementarity.
miR-184 is a microRNA (miRNA), which is small regulatory strands or RNA with 19 25 nucleotides in size [ 94]. miRNA mostly binds to complementary sequences in the 3′ untranslated region (UTR) of mRNA of target genes, leading to mRNA degradation or translational repression.
More suggestions(14)
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bind to unique sequences
bind to unrelated sequences
bind to complementary transcripts
bind to complementary mRNAs
bind to complementary carbohydrates
bind to complementary loci
bind to hybrid sequences
bind to complementary subsets
bind to important sequences
bind to complementary sites
bind to specific sequences
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