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As mentioned above, the picture we have in mind is that proteins such as H-NS, HU, FIS etc. bind to certain regions of the chromosome and give it a compact local structure such that the chromosome consists of a chain of compact units.
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In general, Nrf2 is transferred into the nucleus and binds to certain regions of DNA in a sequence-independent manner [ 13].
Identification of the proteins bound to certain regions of the genome can be difficult but the engineered DNA-binding molecule-mediated chromatin immunoprecipitation method (enCHIP) developed by the Fuji lab was able to use the dCas9 fused to a protein tag to purify specific regions of the genome [ 108].
Governed by the binding free energy of a protein-DNA interaction, some proteins bind more strongly to certain regions of the DNA than the other regions[ 7].
Transcription factors (TFs) are proteins, which bind to certain short sequences (motifs) in the regulatory regions (promoters, enhancers, silencers) of genes.
These results suggest that the GBD also binds to certain variable regions of LigA and LigB.
To mark such internal regions along chromosome arms in the same cell background, we analyzed live UMUC3 cells transiently transfected with HP1α, a non-histone protein that binds to certain heterochromatin regions [ 33].
PcG proteins bind to certain polycomb response elements (PREs).
The activated receptor recruits interacting proteins that bind to certain phosphorylation sites [ 17].
The Yemeni government periodically restricts visits to certain regions.
Their sounds are specific to certain regions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com