Sentence examples for bind to cell surface from inspiring English sources

ML consist of two polypeptide chains: a carbohydrate-binding B-chain that can bind to cell surface receptors and thus enable the protein to enter the cell [ 3- 5]; and the catalytic A-chain which can subsequently inhibit protein synthesis, due to its ribosome-inactivating properties, by removing an adenine residue from the 28S RNA of the 60S subunit of the ribosome [ 3].

These molecules bind to cell surface receptors and are subsequently internalized by endocytosis, resulting in cell death.

In canonical SMAD signaling, TGFβ ligands (e.g., myostatin) bind to cell surface receptors, which initiate receptor-mediated phosphorylation of SMAD2 on its C-terminus (pSMAD2-C), followed by SMAD2 translocation to the nucleus and transcriptional activation23,24.

We hypothesized that linking FGF-1 to a sequence likely to bind to cell surface receptors relatively more abundant on endothelial cells (ECs) might induce a relative greater EC bioavailability of the FGF-1.

Enkephalins and closely related substances known as beta-endorphins were discovered when investigators postulated that since exogenous (produced outside of the human body) opiate substances such as morphine bind to cell surface receptors, there must exist endogenous (produced inside the human body) opiate-like substances that do likewise and therefore have a narcotic action.

Because ADCs are designed to bind to cell surface receptors, trough circulating drug concentrations are typically low.

Receptor-recognized forms of α₂ -macroglobulin (α₂ M) bind to cell surface-associated GRP78 and initiate pro-proliferative and anti-apoptotic signaling.

Bacterial toxins, which specifically bind to cell surface-exposed glycosphingolipids, are a potential novel therapy.

EphA7 (Ephrin type-A receptor 7) can bind to cell surface-associated ephrin ligands on neighboring cells to generate bidirectional signals that affect both the receptor-expressing and ephrin-expressing cells [ 34].

Since it lacks the Fc portion of the antibody, CZP only exerts its activity through binding to soluble and membrane-bound TNF-alfa, and cannot bind to cell-surface receptors for antibodies; consequently, complement fixation and cell lysis do not occur.

The cell-extrinsic apoptotic pathway triggers programmed cell death in response to certain ligands that bind to cell-surface death receptors.