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If a target protein is present, it will bind to binding sites of probe and produce a physical hindrance to ExoIII, which protects the duplex probe from digestion of ExoIII.
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Quenching in isolated LHCII has been proposed to be catalyzed by interactions between chlorophyll molecules bound to binding sites A1 and/or A2 with the lutein in site L1, elicited by a conformational change [ 44].
The lack of VEGFf binding to fibronectin is consistent with an overall reduced ability to bind to ECM binding sites as compared to intact VEGF.
Hit compounds were evaluated and categorized according to their ability to bind to different binding sites in the ATP-binding pocket.
Hyperosmolarity increases the ability of NF-κB and Sp1 to bind to their binding sites.
These ChIP analyses revealed that, in vivo, Hoxd13 efficiently bound only to binding site 2 (Fig. 8).
TCFs bind to ets binding sites present adjacent to CArG boxes in many SRF target gene promoters.
It could be very interesting to identify such chrysin-regulated proteins that bind to STAT binding sites.
To date, the MTLD comprises 1,732 MTLs that bind to 14,996 binding sites extracted from 12,759 PDB structures.
Turning to the Cln3 activator model, it has recently been shown that Cln3 can bind to SBF binding sites across the genome [ 67].
Some of these targets also bind to secondary binding sites of the receptor.
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CEO of Professional Science Editing for Scientists @ prosciediting.com