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It is generally believed that Ag+ can bind to bacterial cell wall membrane damage it and so alter its functionality.
Bug-drugs are able to bind to bacterial cell walls and punch holes in them, killing bacteria.
Fluoride ions can bind to bacterial cell constituents and influence enzymes, such as enolase and proton-extruding adenosine triphosphatase (ATPase).
They bind to bacterial cell membranes, causing disruption of the bacterial cell wall and cell leakage, ultimately causing bacterial cell death.
It is believed, therefore, that phenolic compounds possess the capacity to form complexes with extracellular soluble proteins that bind to bacterial cell wall [ 37].
Though capsular polysaccharides provide a good immune evasion strategy for the bacteria, anti- polysaccharide antibodies efficiently bind to bacterial cell surfaces and facilitate phagocytosis.
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Several studies have been performed on fragments of ubiquicidin both in vitro and in vivo to assess its ability to bind to bacterial cells.
Welling and coworkers [ 51] evaluated the whole 99mTc labeled ubiquicidin and various radiolabeled fragments of the peptide, including UBI1-18 (KVHGSLARAGKVRGQTPK), UBI29-41 (TGRAKRRMQYNRR), UBI18-29 (KVAKQEKKKKKT), UBI 18 35 (KVAKQEKKKKKTGRAKRR), UBI31-38 (RandRMQY), and UBI22-35 (QEKKKKKTGRAKRR) for their ability to bind to bacterial cells and/or human leukocytes in vitro.
In this study, a fusion protein was generated by the union of two cell wall-binding domains, i.e., the Lysin Motif (LysM) domain, which binds to bacterial cell walls, and the pseudomurein cell wall-binding (PMB) domain, which binds to pseudomurein-containing archaeal cell walls.
In addition, CWBDs that bind proteins to bacterial cell walls have been employed in various (medical) applications.
Silver sulphadiazine cream causes a slow and sustained release of silver ions which bind to bacterial deoxyribonucleic acid, inhibiting growth and multiplication of bacterial cells.
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