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Chang, M.K. et al. Monoclonal antibodies against oxidized low-density lipoprotein bind to apoptotic cells and inhibit their phagocytosis by elicited macrophages: Evidence that oxidation-specific epitopes mediate macrophage recognition.
Kuraya and collaborators have reported that ficolins can bind to apoptotic cells and activate the (C4b2b) convertasease [42].
In addition there is – at least – one other molecule with the ability to bind to apoptotic cells multivalently.
The development of radiopharmaceuticals that bind to apoptotic cells has been useful for in vivo evaluation of therapeutic efforts in apoptotic cell death in cardiomyocytes.
The pentraxins share several properties, including the ability to activate the complement system and to bind to apoptotic cells [ 4, 17].
In early apoptosis, phosphatidylserine is translocated to the outer leaflet of the cell plasma membrane [ 17], allowing annexin V labelled fluorophores to bind to apoptotic cells.
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Mfge8, Gas6, and the C1q subunits C1qa, C1qb and C1qc are opsonins, which bind to apoptotic cell surface to initiate phagocytosis.
Gershov, D., Kim, S., Brot, N. & Elkon, K.B. C-Reactive protein binds to apoptotic cells, protects the cells from assembly of the terminal complement components, and sustains an antiinflammatory innate immune response: Implications for systemic autoimmunity.
We identified the antigen recognized by 2E12 antibody as a bovine serum protein vitronectin that binds to apoptotic cells of various origin.
We, therefore, analyzed whether FSAP binds to apoptotic cells.
Annexin allows fluorescent detection of Annexin V bound to apoptotic cells.
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