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The RNase P-based technology is unique, because a custom-designed EGS can bind to any complementary mRNA sequence and recruit intracellular RNase P for specific degradation of the target mRNA.
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This released the end of the hairpin, creating a "sticky end" that was now free to bind to a complementary strand on another nanoparticle.
Each primer was designed to bind to a complementary template immediately adjacent to the mutation site.
miRNAs can bind to a complementary sequence of an untranslated region of target mRNA, and block translation or promote degradation.
For instance, students needed to understand that primers bind to a complementary DNA sequence and prime DNA synthesis of a second strand in the 5′ to 3′ direction.
Antisense oligonucleotides bind to their complementary sequence on messenger RNAs and inhibit translation of the mRNA into the protein.
Anti-mouse IgG coated nanotubes and anti-human IgG coated nanotubes were shown to specifically bind to the complementary antibody-patterned surfaces.
The researchers discovered that the hybrids could also form strands that would bind to other complementary hybrids, which shows that such molecules have the potential to copy themselves.
SNP assays rely on the biochemical principle that nucleotide bases bind to their complementary bases (adenine binds to thymine and cytosine binds to guanine) [ 7].
They can bind to the complementary DNA sequences more stably than DNA itself (Egholm et al, 1993).
MicroRNAs (miRs) are small noncoding RNAs that bind to complementary/partially complementary sites in the 3' untranslated regions of target genes to regulate protein production of the target transcript and to induce mRNA degradation or mRNA cleavage.
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