Sentence examples for bind to antioxidant response from inspiring English sources

The ARENRF2PATHWAY (Oxidative Stress Induced Gene Expression Via Nrf2) is a pathway involved in the oxidative stress through Nrf1 and Nrf2 transcription factors that bind to antioxidant response elements (AREs) (Table 3).

Thus, Nrf2 protein that escapes degradation accumulates and after possible post-translational modifications (e.g., phosphorylation), can enter the nucleus and bind to antioxidant response element (ARE) sequences (5′-TGAG/CNNNGC-3′) that lie on the regulatory regions of its target genes [ 1].

Those can bind to antioxidant responses elements (ARE) in the promoter region of glutamate cysteine ligase catalytic subunit (GCLC), glutamate cysteine ligase modifier subunit (GCLM), glutathione synthetase (GS), glutathione peroxidase (GPx), and ABCC2 genes [ 17, 19], Maher, 2007 #27.

NFE2L2 is a transcription activator that binds to antioxidant response elements (AREs) in the promoter regions of target genes and is important for the coordinated upregulation of genes in response to oxidative stress.

The nuclear transcription factor Nrf2 binds to antioxidant response elements (AREs) and regulates genes involved in protecting cells from oxidative damage.

In conditions of oxidant stress, the transcription factor Nrf2 binds to antioxidant response elements to induce expression of both phase I (acute) and phase II (late-stage) detoxifying enzymes.

In the nucleus, Nrf2 heterodimerizes with small musculoaponeurotic fibrosarcoma (Maf) proteins and binds to antioxidant response element (ARE) consensus sequences (TCAG/CXXXGC) in promoters of Nrf2-regulated genes.

Nrf2 binds to antioxidant response elements (AREs), specific sequences present in the promoter regions of its target genes, as a heterodimer with a small Maf protein, and stimulates transcription of antioxidant proteins [ 4].

NFE2L2 is a transcription activator that binds to antioxidant response elements (ARE) in the promoter regions of target genes important for the coordinated regulation of genes in response to oxidative stress [ 38].

When cells are exposed to oxidative stress, Keap1 undergoes a modification that allows Nrf2 to be released from a complex with it and translocate to the nucleus where it binds to antioxidant response elements of DNA [ 8].

NRF2 binds to antioxidant response elements in the upstream regions of target genes and subsequently activates gene transcription for the antioxidant enzymes such as NQO1 and GCLC, so that NRF2 activation determines an adaptive response to the exposure to oxidant pollutants and provides a pivotal defense mechanism against air pollutants (Lodovici and Bigagli 2011).