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There are good reasons to believe that NTP binding is in equilibrium: in other words, the rates at which NTP molecules bind to, and unbind from, the RNA polymerase are much faster than the catalysis rate.
In that model, CsA can enter and exit the cells, bind to and unbind from the plastic walls and can be metabolized within cells.
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Increasing intracellular [Cl−] from 42 to 140 mM and so increasing the amount available to bind and unbind at intracellular sites had an inhibitory effect on charge displacement and shifted the voltage dependence to more positive potentials (Fig. 4).
We will distinguish three fundamentally different situations: entangled networks formed in the absence of specific cross-linkers, rigidly cross-linked networks showing permanent connection points, and transiently cross-linked networks allowing cross-linkers to bind and unbind.
Indeed, observed large and rapid fluctuations in microtubule growth 18, 19, 22 are consistent with a ragged end structure to which subunits bind and unbind on the millisecond timescale.
In other books, like "The Vanishing Act of Esme Lennox" and "After You'd Gone," women confined to hospital wards slowly reveal secrets that both bind and unbind their families.
Many antagonists are reversible antagonists that, like most agonists, will bind and unbind a receptor at rates determined by receptor-ligand kinetics.
In the eubacterial context, TFs bind and unbind from naked DNA and it was assumed that these processes quickly reach thermodynamic equilibrium.
In addition, we speculate that the agonist can bind and unbind from the receptor in the desensitized state and, similarly as in the case of the closed state, both binding (q) and unbinding (p) are slower in the case of α3β2γ2 receptors.
The proteins can form a dimmer P2 (R5 and R6), which binds and unbinds to DNA (R1 and R2).
A plausible hypothesis that explains these observations is that the PAS domain binds (with relatively high affinity) to another domain on the hERG channel and it positions the flexible N terminal tail region close to the central core of the hERG channel where it binds and unbinds sufficiently rapidly to modulate the rate of deactivation.
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