Sentence examples for bind to and transactivate from inspiring English sources

Mutations of p53, the vast majority within the sequence-specific DNA-binding domain of the protein, produce mutant proteins unable to bind to and transactivate the target genes that mediate tumor suppression [48] [50].

Smads such as Smad3 directly bind to and transactivate collagen gene promoters, and play key roles in cardiac infarct scar formation [ 34- 36].

Furthermore, it has also been shown that ΔNp63 can directly bind to and transactivate a p53-like responsive element in intron 1 of the DGCR8 gene.

Furthermore, we confirmed that SRF could bind to and transactivate both the miR-199a-1 miR-199a-1 miR-199a-1reby upregulandng miR-199a expromotersin GC cells.

The transcription factor serum response factor (SRF) is increased by stretch in avian muscle, and seems to bind to and transactivate the alpha actin gene (Carson & Booth, 1999; Carson, Schwartz & Booth, 1996; Fluck et al., 1999).

Isoflavones are structurally similar to estrogen and genistein and daidzein, but not glycitein, can bind to and transactivate estrogen receptors (ER) with a higher affinity for ERβ [ 9, 10].

This complex binds to and transactivates the TCF/LEF complex.

We demonstrate that Sall2 binds to and transactivates the NOXA promoter under genotoxic stress in vitro and in vivo.

CDX2 binds to and transactivates its own promoter and positively regulates its expression in gastrointestinal human carcinoma cell lines.

Elf3 binds to and transactivates the promoter of CTNNB1 (β-catenin), leading to β-catenin accumulation in cell nucleus.

Following this, P-YB-1S102 P-YB-1S102 P-YB-1S102ivates the EGFR gene, further fueling the growth potential of binds