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Exact(27)
(a) Drugs can bind to and stabilize the polymer.
FH2 domains, comprised of dimers linked by flexible tethers, bind to and stabilize actin dimer intermediates.
Small molecules which bind to and stabilize quadruplex DNA are thus being investigated as potential cancer therapeutics.
Subsequent biophysical evaluation demonstrated that the derivatives could effectively bind to and stabilize c-KIT G-quadruplex with good selectivity against duplex DNA.
Bacillus subtilis ribonuclease P protein (P protein) is predominantly unfolded (D) at physiological pH and low ionic strength; however, small molecule anionic ligands (e.g., sulfate) directly bind to and stabilize the folded state (NL2).
In support of this observation, USP7 has been shown to bind to and stabilize UHRF1 and this interaction is regulated by phosphorylation of UHRF1 during cell cycle (Ma et al., 2012).
Similar(33)
This led us to suppose that, rather than binding to monomeric AS, this neurotransmitter binds to and stabilizes intermediate AS aggregates once they have formed.
β2M is an invariant single domain protein that binds to and stabilizes the larger 3-domain, antigen-binding, variable α-chain component of MHC I. Loss of β2M causes loss of MHC I expression.
HIF1α directly binds to and stabilizes Notch ICD [25, 26] during hypoxia, leading to enhanced activation of Notch downstream genes [27,28,29,30,31].
Here we demonstrate that PsAvr3c, an avirulence effector from oomycete plant pathogen Phytophthora sojae, physically binds to and stabilizes soybean serine/lysine/arginine-rich proteins GmSKRPs.
Scanning transmission electron microscopy (STEM) and atomic force microscopy indicate that NUCB1 binds to and stabilizes heterogeneous prefibrillar hIAPP species.
More suggestions(17)
bind to and use
bind to and confer
bind to and help
bind to and prop
bind to and cross
bind to and release
bind to and destroy
bind to and kill
bind to and activate
bind to and uptake
bind to and facilitate
bind to and enter
bind to and promote
bind to and regulate
bind to and integrate
bind to and stain
bind to and invade
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