(One skeptical early reviewer likened the idea of developing such nanosensors to putting a can opener in the human body). Strano's approach was to take carbon nanoparticles and coat them with a polymer that could bind to glucose and respond to different sugar concentrations.
p75NTR promotes survival by binding tropomyosin-receptor-kinase receptor and enhancing its ability to bind and respond to neurotrophins.
The latter recognizes a conformational epitope of ABP1 overlapping the auxin binding site (SS12S and SS12K lines) thus impairing the capacity of the protein to bind and respond to auxin [10], [15].
Previous work by Dr. Mendelsohn and colleagues showed that retinoic acid receptors (RARs), the proteins required to bind and respond to retinoic acid signals, are necessary for proper kidney development.
Other putative GPCRs that seem to bind and respond to LPA also have been identified (Tabata et al, 2007; Murakami et al, 2008); however, further characterisation as bona fide LPA receptors is still needed.
The tandem Tudor domain protein Spindlin1 from humans recognizes H3K4 methylation [ 15], and can bind to mitotic spindle and respond to DSB [ 16].
In addition, we and others have characterised the ability of HUVEC to bind leukocytes and to respond to cytokines in great detail.
If so, HNF4 could represent a "missing-link" in the evolutionary pathway from a non ligand-regulated transcription factor to a transcription factor that can both bind and respond to ligand.
This excessive glutamate release can lead to excitotoxicity, damage to brain cells through overactivation of the biochemical receptors that bind and respond to excitatory neurotransmitters.
It has been proposed that signaling through TACI in mature B cells or plasmablasts requires higher-order BLyS oligomers or the cross-linking of APRIL through its binding to proteoglycans, whereas BAFF-R and TACI on primary B cells can bind and respond to all forms of BLyS [ 4, 8, 13].
