Sentence examples for bind to and repress from inspiring English sources

Using EMSA and overexpression assays, we thus examined the effect of 5ʹUTR methylation on the binding and activity of SP1, SP3, SUB1 and DEAF1, all of which bind to and repress the GDF5 5ʹUTR (Syddall et al. 2013).

In vertebrates, stem cell transcription factors bind to and repress differentiation genes to maintain the stem cell state (Boyer et al, 2005; Loh et al, 2006).

In plant cells containing low JA levels, JAZ proteins bind to and repress TFs such as MYC2 that promote transcription of JA-responsive genes.

HipB is also translated from mRNA and subsequently binds to a second copy of itself to form the HipB dimer, which can bind to and repress the promoter.

In fact, both NKX2-5 mutants were able to bind to and repress transcription from a known NKX2-5 relementry elementhatat controls the expression of Id3, a gene that inhibits cardiomyocyte differentiation.

Since RIP140 also can bind to and repress many of these transcription factors, including PPARα, PPARγ and ERRα [21,39] it appears that the PGC1α and RIP140 coregulators may play mutually opposing roles in controlling sets of metabolic genes.

Two copies of HipA bind to one copy of the HipB dimer to form the HipB-HipA complex, which can bind to and represses the promoter.

Tcf3 binds to and represses the Oct4 promoter, and this repressive effect requires both the Groucho and CtBP interacting domains of Tcf3 [ 13].

A logical hypothesis for the role of Polycomb in Myc repression is that it directly binds to and represses these targets.

Subsequent work revealed that SNAIL protein binds to and represses (50%) the human VDR gene promoter (Pálmer et al, 2004).

The C/EBPα-Brm complex binds to and represses the promoters of S-phase specific genes [ 29].