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Notably, the ECM can directly bind to and release growth factors; for example, heparan sulfate can bind to and release fibroblast growth factor 2 [ 53].
DOI: http://dx.doi.org/10.7554/eLife.01008.006 10.7554/eLiFigure08.007 Figure 2 figure supplement 3. Arp2/3 complex and diVCA usually bind to and release from filaments as a unit when no daughter filament is formed.
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All cellular functions of HSP70 chaperones seem to depend on an ATP-driven mechanism by which polypeptides are bound to and released from HSP70 [ 82].
For example, Syt1 binds to and releases from the membrane rapidly and is involved in fast synchronous neurotransmitter release, whereas Syt7 has biophysical properties tuned to its roles in slow asynchronous neurotransmitter release and neuroendocrine secretion.
We demonstrated in this study that AMOT can directly bind to and concomitantly release the auto-inhibited conformation of Merlin, thereby promoting Merlin's binding to Lats1/2 and activation of the Hippo pathway.
Significantly it has been shown that while linker and core histones bind to mitochondria and release pro-apoptotic proteins only linker histone H1.2 disrupts the inner membrane potential and causes release of the mitochondrial NAD + pool.
The eosinophils plaster themselves to the worms bound to IgE and release chemicals from their granules that break down the parasite's tough, protective skin.
The conjugates are covalently bound to DOX and release DOX in vivo after administration.
It is obvious that changes in the conformation of the hemoglobin of erythrocytes disrupt its ability to bind and release oxygen, which can lead to incomplete release of oxygen from oxyhemoglobin, its insufficient penetration to tissues, and progression of tissue hypoxia among patients with VD.
Smith's reversible, noncovalent self-assembly processes could be harnessed, he realized, to produce nanoscale molecular systems able to bind and release DNA.
As such, HemQ should be able to bind and release the heme co-factor according to the needs of the organism.
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