Sentence examples for bind to and modulate from inspiring English sources
We have suggested that the secondary sites may bind to and modulate interaction with actin following initial binding via one of the primary sites [19], [20].
The 'inside-out' model of amino acid sensing poses intriguing questions: do amino acids bind to and modulate the V-ATPase from within the lysosomal lumen?
Modularly assembled combinatorial libraries are often used to identify ligands that bind to and modulate the function of a protein or a nucleic acid.
These structures illustrate, for the first time, how small molecules bind to and modulate the activity of a class B GPCR, and highlight the challenges of designing potent receptor antagonists for the treatment of migraine and other class B GPCR-related diseases.
The first selects a reliable therapeutic target that might be essential for an organism's or cell's survival, and then, using chemical library screening, potential leads that bind to and modulate the activity of the target in vitro and subsequently, in vivo, are identified.
In particular, syntaxin 1A has been well-established by our and other laboratories to directly bind to and modulate three Kv channels: Kv1.1 [27], Kv2.1 [28] [30] and Kv2.2 [31].
Here we show that calnexin binds to and modulates trafficking of Cav3.2 channels to the cell surface by altering the retention of the channel in the endoplasmic reticulum (ER).
Abi2 encodes an SH3 domain containing protein that binds to and modulates c-abl activity with effects on cell morphogenesis and motility [25], [26].
The prolyl isomerase Pin1 binds to and modulates numerous proteins involved in cell proliferation, differentiation, DNA damage response, apoptosis and development.
