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Collectively, our data suggest that bisphosphonates bind to and integrate with mineralized surfaces to deter disease progression and cellular growth at the bony site.
In vitro, both drugs bind to and integrate into human DNA and inhibit telomerase.
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As shown in Figure 7a, only a portion of in vitro synthesized, radiolabeled myc-tagged OEP9, Toc33 and Toc34 bound to and stably integrated into (as evidenced by their resistance to extraction with Na2CO3) trypsin-pretreated chloroplasts.
In order for a bacterium to bind, take up and integrate donor DNA into its resident chromosome by homologous recombination, it must first enter a special physiological state termed competence.
Our hope is to synthesize and integrate".
It is essential to educate and integrate refugees, says Tarneden.
As a consequence, a few of them are bound to integrate into a genomic locus that permits autonomous transcription [ 3].
Therefore, we searched for upregulated genes by a combination of controlled Gene Ontology keywords to implicate the extracellular environment (see Materials and Methods) in cancerous cells including those encoded proteins bound to or integrated in cell membranes but whose extracellular domains can be found through shedding in the circulation.
This revealed that sister chromatid cohesion detected by GFP-tagged Tet repressors bound to operators integrated at the URA3 locus was lost in scc3– 1 as well as scc1– 73 cells (Fig. 4A).
The Mediator complex is able to bind to various transcription factors and integrates the transcriptional signals to the basal transcription machinery (Malik and Roeder 2010; Taatjes 2010; Conaway and Conaway 2011; Allen and Taatjes 2015).
We find that individual peptide domains in the hybrid macromolecules bind and partially integrate parallel to the membrane surface, in agreement with experimental findings.
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