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The utilization of a bowl-shaped binding site for a transporter makes practical sense as the substrate must be able to bind to and dissociate readily from the binding site in order for efficient transport to occur.
However, because cross-linking proteins bind to and dissociate from actin filaments, actin-based networks may also exhibit viscous flow.
Next, Marchand et al. (2001) showed directly that VCA regions of WASP family proteins bind to and dissociate from actin and Arp2/3 complex rapidly.
Protein molecules fluctuate, undergo structural changes, bind to and dissociate from interaction partners, and traverse a range of energy and chemical states during molecular action.
Not only bR trimers but also bR dimers and monomers were observed to bind to and dissociate from the crystal edge, these much less frequently than trimers.
It was also suggested and shown in animal models that SGAs actually bind to and dissociate from D2 receptors in an atypical manner (Kapur, 2001).
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Single-molecules of cortactin bound to and dissociated from actin filaments during the time courses of the videos.
Significantly, as shown in panels b and c, very often, collagenase molecules would bind to collagen and dissociate without cutting the collagen molecule.
In contrast, immunohistochemistry with Dvl2HA and Nkd1G2A-myc demonstrated that cells co-expressing both Dvl2HA and Nkd1G2A-myc, but not Dvl2HA alone, have lost the Dvl2HA puncta staining (compare arrows and arrowheads, Fig. 2D F), arguing that Nkd1G2A-myc can still bind to Dvl2HA and dissociate Dvl2HA puncta.
Previous studies have shown that the effective NAC activity (strand-annealing function) of the HIV-1 nucleocapsid protein is correlated with the protein ability to rapidly bind and dissociate from nucleic acids [ 42].
The core molecules in these systems are bacterial regulator proteins that bind to or dissociate from a cognate DNA operator sequence in response to an exogenous stimulus like a small-molecule inducer.
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