The ability of mtCK to bind to and cross-link two membranes explains the contact site formation between mitochondrial inner and outer membranes and the resulting mechanical stabilization of mitochondria as shown with liver mitochondria from transgenic mice expressing mtCK (Speer et al. 2005).
Recently, a paper published in Molecular Pharmaceutics showed that horse spleen ferritin (HosFn) binds to and crosses the mouse BBB because of binding to mouse TfR1 (Chen et al., 2017), which raises great concerns to us.
Cisplatin, the most common first line chemotherapeutic drug, is a platinum compound that binds to and cross-links DNA [ 11].
The outer leaflet of the outer membrane consists of LPS, making it necessary for the peptide to bind to LPS and cross the outer membrane before entering the periplasmic space (Farnaud et al. 2004; Bhattachariya and Ramamoorthy 2009).
Carbapenems, like all β-lactam antibacterials that bind to and inhibit the peptidoglycan cross-linking transpeptidases, were specifically designed to resist the action of β-lactamases with activity against penicillins and cephalosporins.
However, because cross-linking proteins bind to and dissociate from actin filaments, actin-based networks may also exhibit viscous flow.
GA is a homobifunctional cross-linker that can bind to and covalently link molecules through their free amines.
In procuticle, a grouping of what has been called the exo- and endocuticle, cuticular proteins bound to chitin and cross-linked with the sclerotizing agents form one of the most infrangible known biological coverings [ 1].
Antibody-sensitized MCs can become activated during a secondary challenge when the sensitizing-antigen binds to Ig and cross-links the FcRs or can be activated through binding of immune complexes that have already been formed (Oshiba et al., 1996; Malbec and Daëron, 2007).
The way it operates is forming a platinum complex inside of a cell which binds to DNA and cross-links DNA.
