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We identify potential protein interactions that appear to directly bind to and alter the biophysical properties of the MreB cytoskeleton.
PG-11144 could bind to, and alter, chromatin structure, thus decreasing the ability of LSD1 to target the nucleosome at specific chromatin sites, thereby leading to a decrease of LSD1 occupancy at the SFRP2 promoter.
FKBP5 is known to bind to and alter the function of steroid hormone receptors, including the GR [ 44] and is a negative feedback regulator of GR function [ 31, 45].
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Binding to and altering the properties for plasminogen and factor VIII may be the molecular basis to link the clinical and pathological relationship between dengue infection and haemostatic abnormalities such as vascular leakage, thrombocytopenia and hemorrhage [ 19, 20].
These maintenance proteins form heteromultimeric complexes that bind to chromatin and alter its structure.
Besides opsonins, other proteins in blood such as albumin and apolipoproteins may bind to GNPs and alter their cellular uptake [ 27].
Improved understanding of the sequence rules by which small molecules bind to DNA and alter patterns of gene expression advances both basic and applied research.
We show that this α-helical motif can bind to membranes and alter the shape of liposomes with a lipid composition resembling that of the peroxisomal membrane, thereby causing extensive tubulation.
We speculate that this may be related to the observation by Alani and colleagues that the Msh2-Msh3 heterodimer both binds to and alters the conformation of the junction between 3' ssDNA and dsDNA, and that this conformational change may facilitate cleavage by Rad1-Rad10 [50].
Researchers have previously been able to visualize the three-dimensional structure of psalmotoxin attached to ASIC, which revealed how the toxin binds to and alters the activity of the ion channel.
These molecules have the ability to bind and alter protein-protein interaction that plays a key role in cellular responsiveness in development, homeostasis, and disease [ 34].
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CEO of Professional Science Editing for Scientists @ prosciediting.com