Sentence examples for bind to adjacent sites from inspiring English sources

Similarly, when two factors bind to adjacent sites on DNA (co-binding), they may not actually interact with each other, i.e. no cooperative interactions.

Plakoglobin and β-catenin bind to adjacent sites on Tcf-4 and plakoglobin inhibits binding of Tcf-4 to DNA (Miravet et al, 2002).

DND1 has been shown to bind to the 3'-UTR of mRNAs to displace miRNAs that bind to adjacent sites on the same mRNA [8].

Expression of FGF4, therefore, requires the combined activity of these two transcription factors that bind to adjacent sites on the FGF4 enhancer DNA region [ 59].

In an attempt to understand the sources of this strain, we have solved the 2.2 Å resolution X-ray crystallographic structure of a complex that has two copies of the three-finger Zif268 protein bound to adjacent sites on one duplex DNA.

They base this on the observation that models in which the effects of activators can simply be added to those of repressors are sufficient to produce the stripe 2 pattern, and there is no need to assume that activators bound to adjacent sites cooperate with each other to augment their activities.

Collectively, these observations suggest that Hoxa2 and Meis bound to adjacent sites on DNA could reinforce each other's occupancy by direct protein-protein interactions (Spitz and Furlong, 2012; Williams et al., 2005), although indirect mechanisms (e.g., the requirement of additional proteins that bridge Hoxa2 and Meis) cannot be excluded at this stage.

The reason for this discrepancy is that while NFAT can alone bind to and activate the CD40L promoter, binding to the IL2 promoter requires AP1 binding to adjacent sites.

The Fok I domains on the two monomers designed to bind to adjacent DNA target sites will form a dimer, in turn become activated, generating DNA double-strand break (DSB) at the spacer region between two EBEs.

Site-specific cross-linking shows that the chromodomains and ATPase motor bind to adjacent SHL1 and SHL2 sites, respectively, on nucleosomal DNA and pack against the DNA-binding domain on DNA exiting the nucleosome.

We have identified AP-1 as one of the collaborating transcription factors that preferably bind to the adjacent sites surrounding STAT1 binding regions.