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Furthermore, binding of podocytes to Matrigel-coated plates also could not be inhibited by IIH6, which not unexpectedly suggests that podocytes also can bind to additional molecules without laminin G modules.
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While we have demonstrated attenuation of PDGF and IFN-γ, it remains possible that DS-SILY20 binds to additional signaling molecules that also contribute to the observed activity.
This indicates that the larger s20,w observed for the complex formed on the RND substrate originates from different conformations and/or large conformational changes rather than from the ability to bind one additional molecule.
Binding additional molecules to a nucleic acid backbone can expand the chemical functionality of nucleic acid based scaffolds.
Equation (1) describes how the Mad1 C-Mad2 core complex binds additional molecules of O-Mad2 through formation of conformational heterodimers between the C- Mad2 subunit of the Mad1 C-Mad2 complex and O-Mad2.
Antibodies can bind to these molecules to prevent invasion.
Others bind to specific molecules on one side of a membrane and transport the molecules to the other side.
In perfect conditions, a single molecule of avidin would bind to four molecules of biotin.
To date, it has been demonstrated that intracellularly expressed affibody molecules can bind to target molecules and inhibit their functions.
Cationic polymers can bind to DNA molecules to form neutralized, nanometer-sized complexes known as polyplexes.
The first PTB molecule bound to P3 or DY might interfere with subsequent binding by additional molecules.
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