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Recently, specific HIF2α inhibitors that bind to a unique cavity in HIF2α were developed [55, 56].
In principle, an aptamer can specifically recognize and bind to a unique ligand, leading to a structural change of an aptamer.
Peptide or small molecule ligands that bind to a unique region of a protein can be used for orienting the protein and modulating its activity through specific ligand-protein interactions on a solid support [11] [13].
In addition, these two factors each bind to a unique set of targets as well.
Only antibodies that will bind to a unique epitope will react specifically to its intended target protein.
Although type III IFNs bind to a unique heterodimeric IFNλ receptor complex, they induce a type I IFN signaling pattern (12).
Similar(51)
REST is unique: it binds to a unique sequence that allows identity of the binding sites both bioinformatically and by ChIP; the gene targets represent a large set of proteins that are essential for terminal neuronal differentiation, a specific transition during differentiation; and REST is present in ESCs, where these targets are repressed, and minimally expressed at terminal differentiation.
In addition to using firewalls for this purpose, Wu et al. [20] also employ subnetting (i.e., each virtual network is bound to a unique subnet) in order to provide an additional layer of security against unauthorized information disclosure.
The CART receptor has yet to be identified, but there is significant evidence that CART binds to a unique Gi/Go-coupled.
In theory, each unique hexapeptide binds to a unique protein recognition site.
It binds to a unique ligand, ICOSL, and does not bind to other ligands such as B7-1/B7-2 B7-1/B7-2 B7-1/B7-2
More suggestions(20)
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