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While NTs bind to a specific Trk receptor, all of the NT molecules can bind to p75NTR, which has important physiological implications on neurons.
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Neurotrophins bind to their specific high-affinity receptors tyrosine kinase (trk) A (NGF), trkB (BDNF, NT-4), and trkC (NT-3), and to one low-affinity receptor p75 (or NGFRp75) that binds to all ligands.
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