The corresponding protein region (the homeodomain), about 60 amino acids long, binds to a short stretch of DNA in the regulatory region of the target genes.
Beside them in the mud, in a jumble of broken boards and torn plastic, lay a grave marker, a piece of wood the size of a checkbook bound to a short plastic pole.
Unlike magainin 2 amide, a prototypical membrane disruptive AMP, buforin II amide adopts a poorly helical structure in membranes closely mimicking the composition of Gram negative bacteria, such as Escherichia coli, and binds to a short duplex DNA sequence with high affinity, ultimately forming peptide DNA condensates.
Instead, we demonstrate that the TCP domain of CPAP constitutes a novel proline-rich-motif (PRM) recognition-domain that specifically binds to a short target motif in STIL.
We first assessed the effects of the A481T mutation on Ago2 by determining the crystal structure of the mutant protein bound to a short target RNA bearing a t1A nucleotide (Table 3).
Further, a region within the c-terminal RhoGAP-like domain of OCRL, in which several disease-causing mutations are found, binds to a short phenylalanine and histidine (F&H) motif found within the endocytic adaptors APPL1 and Ses1/2 (19, 19).
In fruit flies, dosage compensation relies on a male-specific molecular complex that binds to a short sequence of DNA found multiple times across the X chromosome (Conrad and Akhtar, 2011).
RNase concentrations in the 1/10,000 1/30,000 range yielded a focused band indicative of FLAG MKRN1 bound to a short fragment of RNA protected from RNase by MKRN1 (Figs 2E and EV2F).
If Kaiso binds to a short region of highly methylated DNA that is not exactly in the middle of a peak having an overall low level of DNA methylation, then it is possible that a relationship between Kaiso binding and DNA methylation is obscured when the analyses are centered on the middle of the genomic regions identified by the peak-calling program.
