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RNA interference: Cutting mRNA The small interfering RNA will bind to a segment of messenger RNA that matches its sequence, triggering the messenger RNA to split and rendering it useless.
Signal molecules bind to a segment of the receptor called the extracellular domain that faces out from the cell.
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A unit in which a molecule of a histone is bound to a segment of the DNA chain of genetic material is termed a nucleosome.
Sangamo scientists have engineered a library of 10,000 fingers by tinkering with the variable region, designing it so that it will seek out, recognize and bind to a specific segment of DNA for a specific gene.
Gene expression can be activated or inhibited when proteins (transcription factors, TFs) bind to a genomic sequence segment (i.e. motif) dispersed in promoter and enhancer regions.
Gene regulation is a complex process that usually involves the cooperation of multiple transcription factors, which may interact to form a regulatory module that binds to a DNA segment to regulate their target gene's expression.
Through phage display, we have isolated 10 engineered Forkhead-associated (FHA) domains that selectively bind to a phosphothreonine (pThr -containing pThr -containingpeptidePS-64) 53-FELLPpTPPLSPS-64 53-FELLPpTPPLSPS-64 53-FELLPpTPPLSPS-64
The procedure starts from a co-crystal structure of a ligand bound to an amyloidogenic segment of Aβ (Landau et al., 2011), the dye orange G bound to the fiber-like crystal structure of KLVFFA(Aβ16 21) segment.
In its dozens of hitherto identified binding partners DYNLL binds to a linear peptide segment.
In addition, we present a structure of the Wapl domain bound to a functionally relevant segment of the Smc3 ATPase.
T cell superantigens bind to Vβ segment of T cell receptor and activate a huge proportion of T cells.
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