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The going theory for this--that antibodies generated by a first bout with dengue bind to a second strain, which helps it multiply in the immune cells--doesn't account for the internal bleeding and tissue damage, says Juthathip Mongkolsapaya of Mahidol University in Bangkok, Thailand.
When HIV infects cells, gp120 first binds to the CD4 receptor on white blood cells and then "transitions" in such a way that hidden parts of the virus are exposed, allowing it to bind to a second receptor on the immune cells called CCR5.
Interestingly, in the several structures of bacterial Pdx1's that have been determined so far, sulfate, chloride or phosphate ions were shown to bind to a second site, referred to as P2, located at the hexamer interface of the Pdx1 dodecamer [17] [20].
Peptides are displaced from strong-cation-exchange resin using a salt step gradient and subsequently bind to a second reverse-phase media.
The analysis revealed the shape of a single p66 protein molecule, and showed that occasional changes in shape allow one p66 molecule to bind to a second.
In this study, we found that PTPδ can specifically trans-synaptically bind to a second and a third partner, IL1RAPL1 and its paralog IL1RAPL2.
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If a dimerizing ligand were present, it would simultaneously bind to a first peptide on a first nanoparticle and a second peptide on a second nanoparticle, thus causing bulk crosslinking of nanoparticles and peptides.
All bind the major VEGF-A receptors (VEGFR-2/Flk and VEGFR-1/Flt), and all except VEGF-A120/1 VEGF-A120/1hird receptor, neuropilin.
For affinity fusion proteins, the appended protein will bind to a third, typically small, molecule that is immobilized on the surface of a polymer resin.
Recently, it has become clear that PIWI subfamily proteins bind to a third class of small RNAs called PIWI-interacting RNAs (piRNAs) [ 16- 19].
Both Geldanamycin (GA), which binds to the N-terminal ATP-binding site of the protein [ 22], and Novobiocin (NB), which binds to a second ATP-binding site on the C-terminal domain [ 23] are global Hsp90 inhibitors: that is, they are known to block both Hsp90 isoforms (α and β), which share about 80% homology, and maybe other factors.
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