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Moreover, it can even bind to a random DNA sequence equally well (Fig. 2D).
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Nucleic-acid aptamers, which are normally selected from a large random-sequence pool to bind to a specific target molecule, have been explored for targeted siRNA delivery as an alternative to antibodies.
The rEGSs consisting of the random 14-nucleotide sequence (N14) and a cytosine (C) were designed to bind to a G nucleotide in the target RNA.
Although it was possible that the actin filaments could be bound to a spindle matrix [28], the orientation of the filaments was not random.
Gabapentin binds to a channel.
Nvp63 bound to the canonical p53 RE with twelve fold higher specificity than to a random DNA sequence.
"I was speaking to a random woman.
By applying the Chernov bound to the random variate E y, we obtain Pr { | E y − E E y | ≥ δ } ≤ 2 · exp − δ 2 / 2 σ E y 2. Thereby, in order to demonstrate (12), it suffices to show that E E y = E z and Var E y = o ( P ) for the case under concern.
These results suggest that AIRE binds to chromatin in a random fashion and/or that the binding is dynamic.
If, on the other hand, the substrates bind in a random fashion, all four reactions have an equal probability of occurrence.
The photons arrive to voxels from nearby fluorophore molecules in a random Poisson process; likewise, the fluorophore marker molecules bind to the nearby synapses in a random Poisson process.
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