As the mobile liquid phase slowly percolates through the stationary column, each As III) solute progressively binds to a multitude of Fe III) sorption sites favoring As III) oxidation.
MIP controls the intracellular levels of PI[ 3, 5]P2, which in turn binds to a multitude of proteins [ 28- 30], therefore working as a principal molecule in the coordination of intracellular networks [ 28, 31].
Another way in which p300/CBP is able to respond to signaling pathways is due to the ability of p300/CBP to bind a multitude of different proteins, using its various protein-interacting domains.
These novel diagnostic agents produce high contrast images due to their fast clearance from the bloodstream and healthy tissues, can be evolved to bind a multitude of cancer biomarkers, and are easily functionalized by site-specific bioconjugation methods.
These proteins are able to bind a multitude of different signaling proteins including kinases, phosphatases and transmembrane receptors and play a major role in modulating a wide range of regulatory processes such as mitogenic signal transduction, cell cycle control, ion channel regulation, and apoptosis [36].
A striking feature of the 14-3-3 14-3-3 14-3-3heir ability to bind a multitude of functionally diverse signaling proteins, iscluding kinases, phosphatheir, abilitynsmembrane receptors.
Evidence here and elsewhere [ 37- 41], suggests that disordered regions may be an extremely common mechanism by which hub proteins bind to their multitude of partners.
This idea, which is an extension of a previous proposal [ 117], further suggests a general mechanism by which hub proteins could bind to such a large multitude of partners, which cannot be explained from the view point of interaction between two structured proteins [ 51].
