Sentence examples for bind to a large from inspiring English sources

These proteins differ from classical C-type lectins in that they lack the calcium and sugar-binding loop and instead bind to a large variety of proteins and receptors involved in hemostasis, including coagulation factors IX and X and various blood platelet receptors [ 72].

The endogenous glycoprotein hormones of GPHRs bind to a large extracellular orthosteric binding site leading to receptor activation by triggering the transmembrane domain [ 17, 18].

Protein recognition by synthetic molecules is a challenging endeavour, since these materials must bind to a large relatively flat surface domain and recognize a unique distribution of amino acid residues of varying charge, size and shape [1].

Peptides are well suited as the bioreceptor component of various biosensors and biomedical applications because they can selectively and tightly bind to a large diversity of biomolecules, including DNA, RNA, and protein targets through modification of their multi-linking polychains [19, 20].

Scavenger receptors bind to a large range of molecules on the surface of bacterial cells, and Toll-like receptors so called because of their similarity to well-studied receptors in fruit flies that are encoded by the Toll gene bind to more specific molecules.

This finding is in line with previous studies, which have shown that it is much more difficult to affect ricin than Stx transport, maybe due to its ability to bind to a large variety of receptors.

The results reveal that the new derivatives are less mobile and bind to a larger pocket in the channel.

Also, compared with local TFs that tend to have high-affinity sites, global TFs are less specific, bind to a larger collection of sites and must be expressed at higher levels (Lozada-Chavez et al., 2008; Martínez-Antonio et al., 2008).

The experiments reveal that the MHC class I molecules that can bind to a larger variety of protein fragments (so-called 'generalists') are present in lower numbers on the surface of cells than molecules that can bind to a smaller variety of fragments (so-called 'specialists'specialists

A statistically relevant hit to a binding site bound to a large ligand with smaller cognate similarity might offer equal or greater relevant functional clues as a hit to a smaller ligand with greater cognate similarity.

At the biochemical level, the KD binds to ATP as the only ligand, whereas the PBD binds to a large spectrum of binding targets, such as Plk1-binding proteins and physiological substrates (Park et al. 2010).