Sentence examples for bind to a gene from inspiring English sources

Binding information is essential because transcription factors must first bind to a gene to induce or suppress expression, while conservation information is important because true-positive transcription factor-DNA interactions are often conserved within a genus.

Typically, several TFs can bind to a gene's promoter and different TFs may compete for binding sites.

For each known gene, the Entrez Gene ID (formerly known as Locus Link ID) is assigned using the KnownToLocusLink table, and the list of transcription factors that bind to a gene promoter region (±2,000 bp of TSSs) was generated using minimal overlap.

Although match scores can approximate the opportunity for a transcription factor to bind to a gene promoter region, it is also meaningful to determine a threshold for match scores to evaluate whether the transcription factor binds and regulates the transcription of specific genes.

We assume that when at least one activator is bound to a gene, the transcription is activated with a particular production rate for each combinatorial possibility of all the remaining binding sites.

Rb binds to a gene regulatory protein called E2F and blocks the transcription of S-phase genes.

These experiments corroborate our previously described model of gene regulation by unliganded GR in which GR binds to a gene promoter in the absence of HC to activate expression, and in the presence of HC, the activity of the gene decreases due to the dissociation of GR from the promoter.

The model is based on the following assumptions: Each gene has a number of TF binding sites in its promoter region Each protein has a number of binding domains, with each binding domain being able to bind to a specific gene.

Under the correct cellular circumstances, Transcription Factors (TF's), in coordination with transcriptional co-factors, ligands, the appropriate signalling cascade and a receptive chromatin structure, will bind to a target gene's promoter region culminating in a targeted gene expression response.

For example, a common belief was that a specific transcription factor could bind to a few dozen genes whose core promoters contain its consensus binding site as defined in vitro, and once recruited to a promoter could almost single-handedly regulate transcription [ 13].

It has been reported that multiple miRNAs bind to a single target gene, a phenomenon known as cooperativity (51, 52).