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These strands will bind to a fragment of the genetic material of a biological agent, such as anthrax.
First, the TCR must recognize and bind to a fragment of the pathogen that is presented to it by an innate immune cell.
To test whether this region of STIL could bind to the CPAP TCP domain, we recombinantly produced the TCP domain of Danio rerio CPAP and used isothermal titration calorimetry (ITC) to test its ability to bind to a fragment of D. rerio STIL that spanned CR2 (residues 404 448).
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The structures of ACE2 bound to a fragment of the SARS spike containing the receptor-binding domain and the pre- and post-fusion configurations of the fusion core heptad repeats of the spike have been solved to atomic resolution [2], [3], [24] [26].
Jayaraman et al. present a 3.2 A resolution crystal structure of a Rev dimer bound to a fragment of RNA corresponding to the high-affinity binding site (Stem loop IIB) of the Rev-response element (RRE) plus the adjacent IIABC junction.
Although, it is believed that integrin is in extended form when binding ligands, there is also evidence based on electron microscope analysis indicating that the extodomain of integrin bound to a fragment of fibronectin (F7 F10) appears to be in a similar compact (bent) conformation as the unbound extodomain [29].
The mouse myosin VI CBD binds to a fragment of the clathrin-coated vesicle adaptor Dab2 with high affinity.
Jayaraman et al. now provide the first in-depth 3D structure of two Rev molecules bound to a fragment of the Rev Response Element.
The EMSA results clearly revealed that nuclear protein(s) extracted from Tapidor leaves specifically bound to a fragment (ES7) from the middle of the Monkey King sequence, almost entirely composed of A/T bases (Fig. 6b and Additional file 4).
Furthermore, the nuclear-localized SIRT1 is not associated with PLZF repressor function but nevertheless binds to a fragment of the zinc finger domain of PLZF similar to that we had previously described for the RING finger protein promyelocytic leukemia protein (PML) ([ 42] and data not shown).
The dephosphorylated form of Maf1 can associate with pol III, and recombinant Maf1 can bind to a protein fragment corresponding to the N-terminal 235 amino acids of the largest pol III subunit [19].
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