Sentence examples for bind to a folded from inspiring English sources
Fast protein binding also typically requires proper orientation of the protein binding partners as well as conformational adaption of the IDP to bind to a folded protein.
The therapeutic small molecule might bind to a folded mutant protein to restore its stability to that of WT, and/or bind to a non-native conformation and accelerate folding to the native state.
Furthermore, addition of a disordered region of Nephrin containing multiple phospho-tyrosine residues, which bind to a folded SH2 domain within Nck, enhances multivalent interactions and further lowers the critical concentration for phase separation.
The neomycin portion of neo-acridine binds to the same sites as neomycin, while the attached acridine group appears to bind to a duplex region in the main stem of the folded 171-mer.
Normally, the substrate of an enzyme might help the refolding process, but the study here showed that G6P had no positive effect, even though our kinetic studies [ 27] would indicate that the sugar phosphate substrate can bind to the folded enzyme in the absence of coenzyme at the active site.
Similarly to malectin and Glc2Man9GlcNAc2 glycoproteins, the ER lectins CNX and CRT bind to incompletely folded or misfolded α1AT in the ER; however, they do so via Glc1Man9GlcNAc2 glycans (Ou et al., 1993; Le et al., 1994; Wu et al., 1994).
Many of them have been developed to bind to folded proteins, yet cellular networks for signaling and protein trafficking often depend on binding to unfolded regions of proteins.
NMR studies using the full-length 4E-BP revealed that phosphorylation of 4E-BP results in a transition from a binding-competent disordered state to a folded state that cannot bind to eIF4E [ 99].
However, the overlay of C12M02 with an amino quinazoline MAP4K4 inhibitor that binds to the folded P-loop conformation shows how similar the suggested binding mode of C12M02 is to the binding mode of the amino quinazoline lead (Figure 8d, [27], PDB ID: 4OBO).
This small molecule rapidly binds to natively folded TTR tetramers, arresting further subunit exchange while remaining nonfluorescent.
