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For example, a common belief was that a specific transcription factor could bind to a few dozen genes whose core promoters contain its consensus binding site as defined in vitro, and once recruited to a promoter could almost single-handedly regulate transcription [ 13].
It has been demonstrated by chromatin immunoprecipitation studies that Oct4 and Sox2 bind to a few thousand regulatory sites in the ES cell genome [3], [4] and likely that many of these target genes play a modulating role in ES cell differentiation.
Because an individual Mhc molecule can recognize and bind to a few antigens only, which is determined by the amino acid composition in their antigen-binding site (ABS), gene duplications and polymorphism at the ABS are thought to be adaptations enabling individuals to respond to a greater variety of antigens [ 13].
Upon closer inspection, the high number of indirect paths is mainly due to binding interactions of a single set of proteins (including differentially expressed Mapre3, Cep57, Tubg1 and Nedd1) that are not annotated to a pathway, but do all bind to a few proteins that play a role in many different pathway interactions, such as Ywhab, Prkaca, Tubb5 and Hsp90ab1.
Second: although the bromodomain of Brd4 binds to acetyl-lysine residues on histone-4, and I-BET151 was modeled to inhibit this interaction, it is now known to bind to a few non-histone chromosomal proteins as well, notably NF-κB, a liaison also blocked by BET-protein inhibitors (Huang et al., 2009; Zhang et al., 2012; Zou et al., 2014).
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It has been proposed that DnaA first binds to a few high affinity DnaA boxes followed by binding to low affinity DnaA boxes to form a productive DnaA oriC initiation complex [23].
This MAb only binds to a few specific proteins in the hazelnut extract (see Fig. 1, lanes B1 and B2) whereas PAbs can bind to a whole range of proteins.
Anyone involved in the political wars as long and as relentlessly as Madison was surely bound to make a few missteps, and a few enemies, along the way.
Mentioning anything cat-related on a decor site is bound to get a few eye-rolls and maybe a sigh.
If you're an RT devotee (there's bound to be a few of them, right?), make it a point to play with one.
In Ireland, where abortion remains illegal, such a project is bound to touch a few nerves.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com