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The myriad functions of HSPGs in growth and differentiation of cells [16] are mediated through their ability to bind to a diverse repertoire of growth factors and morphogens.
Appl1 and Appl2 are homologous proteins that bind to a diverse set of transmembrane receptors or signaling proteins.
They can recognize and bind to a diverse range of antigens including polypeptides, carbohydrates, lipids, nucleic acids, or even small hapten molecules.
In contrast to TRBV, TRBD and TRBJ genes which encode products that bind to a diverse array of peptide-MHC ligands, TRBC gene products interact with components of the CD3 complex which are non-polymorphic.
This is largely due to the intrinsic nature of RNA molecules and their ability to form complex secondary structures, which enable them to bind to a diverse set of molecules, such as DNA, RNA, and proteins.
In mammalian cells, members of the G-protein-coupled receptor family, which couple primarily to heterotrimeric G-proteins and β-arrestins, initiate a wide range of signaling events involved in several cellular processes when they bind to a diverse array of ligands, such as hormones and peptides (Musnier et al., 2010; Shukla et al., 2011).
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In the S. aureus multidrug binding repressor protein QacR, which binds to a diverse yet precise array of cationic compounds, it was predicted that glutamate residues lining the multidrug binding pocket would play a key role in drug binding affinity.
Ubiquitin like proteins (UBLs) are post translationally bound to a diverse group of other proteins thereby increasing the functional diversity of the encoded proteome.
Using a combination of laboratory assays and computer algorithms, the team tested various mutations in HB36.5, looking for single amino acid changes that would increase how tightly the protein bound to a diverse group of hemagglutinins.
Results of long-term aging experiments demonstrate that unbound prions or prions bound to a diverse range of soil surfaces can readily replicate after one year.
A set of Δ Tm values measured for a given enzyme bound to a diverse panel of ligands can, therefore, provide a fingerprint that is characteristic of the ligand binding properties of that enzyme.
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